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It is also used non-medically for physique- and performance-enhancing purposes.
Metandienone is a substrate for aromatase and can be metabolized into the estrogen methylestradiol (17α-methylestradiol). As with other 17α-alkylated steroids, methandienone poses a risk of hepatotoxicity and use over extended periods of time can result in liver damage without appropriate precautions. Androgenic side effects such as oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization may occur.
Metandienone, also known as 17α-methyl-δ1-testosterone or as 17α-methylandrost-1,4-dien-17β-ol-3-one, is a synthetic androstane steroid and a 17α-alkylated derivative of testosterone. The co-administration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like tamoxifen can reduce or prevent such estrogenic side effects. As  comprar clenbuterol com entrega , it can cause side effects such as gynecomastia and fluid retention. Methandienone binds to and activates the androgen receptor (AR) in order to exert its effects. Estrogenic side effects such as gynecomastia and fluid retention can also occur. Metandienone, along with other AAS, is a schedule III controlled substance in the United States under the Controlled Substances Act.
The former synonym should not be confused with methylandrostenolone, which is another name for a different AAS known as metenolone. Non-medical use was outlawed in the U.S. under the Anabolic Steroids Control Act of 1990. Generic production shut down two years later, when the FDA revoked metandienone's approval entirely in 1985. FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.
Metandienone is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters. Metandienone is readily available without a prescription in certain countries such as Mexico, and is also manufactured in some Asian countries.  testosteron verhogen supplementen kopen  is currently a controlled substance in the United States and United Kingdom and remains popular among bodybuilders.
There are many known cases of doping in sports with metandienone by professional athletes.  vanbox  is the generic name of the drug and its INNTooltip International Nonproprietary Name, while methandienone is its BANTooltip British Approved Name and métandiénone is its DCFTooltip Dénomination Commune Française. After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the U.S. In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism. It is a modification of testosterone with a methyl group at the C17α position and an additional double bond between the C1 and C2 positions.
It was also prescribed off-label as a pharmaceutical performance enhancement to weight lifters and other athletes. The primary urinary metabolites are detectable for up to 3 days, and a recently discovered hydroxymethyl metabolite is found in urine for up to 19 days after a single 5 mg oral dose. The elimination half-life of metandienone is about 3 to 6 hours. It has very low affinity for human serum sex hormone-binding globulin (SHBG), about 10% of that of testosterone and 2% of that of DHT. As with other 17α-alkylated AAS, metandienone may be hepatotoxic, especially with prolonged use of high doses.
It is also referred to as methandrostenolone and as dehydromethyltestosterone. The drug is also the 17α-methylated derivative of boldenone (δ1-testosterone) and the δ1 analogue of methyltestosterone (17α-methyltestosterone). As the CIBA product Dianabol, metandienone quickly became the first widely used AAS among professional and amateur athletes, and remains the most common orally active AAS for non-medical use. Metandienone, also known as methandienone or methandrostenolone and sold under the brand name Dianabol (D-Bol) among others, is an androgen and anabolic steroid (AAS) medication which is mostly no longer prescribed.